PH-D7-Osteoarthritis

Sally is a 50-year-old female who has been a jogger for several years. She has recently been diagnosed with osteoarthritis. She has been taking ibuprofen for 3 months but states that “it does not help” and hurts her stomach. The health care provider prescribes celecoxib (Celebrex) 100 mg orally twice a day.

1. What is the first-line therapy for osteoarthritis and the mechanism of action?
2. Sally expresses concern about all the recent news about heart problems and celecoxib (Celebrex). What information should be included in a teaching plan to help her understand about taking celecoxib and the benefits and risks?
3. Ibuprofen and celecoxib are both nonsteroidal anti-inflammatory drugs. Explain how they are similar and different

Submission Instructions:

• Your initial post should be at least 500 words, formatted and cited in current APA style with support from at least 2 academic sources.

Answer preview

Osteoarthritis (OA) is an arthritis disease that wears down the bone’s flexible tissue. Treatments of OA help alleviate pain and improve body functioning. It is more likely to develop with age as it occurs slowly with time. Some other causes include joint injuries, deterioration of tendons, and breakdown, which causes pain and joint deformation (Sharma, 2021). The first-line therapy for OA treatment is acetaminophen used for treating mild and intermittent symptoms. However, when acetaminophen is not helping relieve pain, or the symptoms worsen, nonsteroidal anti-inflammatory drugs (NSAIDs) is prescribed nonsteroidal. The mechanism action for acetaminophen is to activate descending serotonergic pathways by inhibiting the COX pathway in the central nervous system.

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