Requirements: As the assignment needs
There is an increased use of computational methods in gene finding and genome editing in DNA sequences. This increases its use in the treatment/cure of various diseases. Gene prediction is important for sickle cell anemia, a common monogenic disease (Kuo, 2017). However, there are limited gene-finding tools for rare disease conditions since, despite patients having the same biochemical phenotype, there is considerable clinical heterogeneity. The availability of single-nucleotide polymorphisms (SNPs) leverages the value of computational methods in treating these diseases. CRISPR/Cas9 is a genome editing technique that has proved useful for various functions, including treating various conditions (Karimian et al., 2019). This research proposal is based on an analysis of the use of CRISPR/Cas9 to treat a rare disease, sickle cell anemia.