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Case study #3
Kevin worked for 10 years at a uranium mine, excavating uranium for a nearby nuclear power plant. Now, 25 years later, he has small cell lung cancer. Kevin is anorexic and has lost a considerable amount of weight. His muscles are wasting, and he is weak. He tries to move around the house throughout the day but tires easily. It has been difficult for him to access care, and the treatment for his cancer is just starting.
In some cancer patients, muscle weakness may result from the production of onconeural antigens. Describe the effects of these antigens. What form would this process likely take in Kevin’s situation?
Answer preview
Due to the development of tumors, some factors produced have been discovered to facilitate muscle wastage by blockage of muscle repair. Normally, muscles regenerate from stem cells that are always present in the body. The cells fix muscles by fusion with the surrounding muscle fibers in order to increase the mass of muscles. The deal with muscle fixation in cancer patients is caused by some effects from the condition. There is usually the inability of muscles to recover. This is because the process of muscle regeneration is halted at a point in between their recovery. The alteration is caused by the overexpression of Pax7. This substance has the role of regulating muscle stem proliferation. Muscle recovery is unable to happen due to the effect of the cancerous growths on the functionality of the stem cells. This is the reason as to why cancer
